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Query: NC_007530:4176462:4192302 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 4192302, End: 4192568, Length: 267

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011969:4065460:407843840784384078815378Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-46182
NC_017200:4191963:420362442036244203890267Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein1e-45181
NC_011658:4171237:418307841830784183344267Bacillus cereus AH187 chromosome, complete genomehypothetical protein1e-45181
NC_014335:4113154:412399141239914124257267Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-45181
NC_005957:4169610:418145941814594181725267Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-45181
NC_011772:4321117:433029343302934330559267Bacillus cereus G9842, complete genomehypothetical protein4e-45179
NC_010184:4219257:422873342287334228999267Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF9654e-45179
NC_020272:1311932:131465313146531314919267Bacillus amyloliquefaciens IT-45, complete genomehypothetical protein3e-34143
NC_018870:1695588:169887716988771699191315Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein DUF9652e-23107
NC_020995:2636519:265023726502372650503267Enterococcus casseliflavus EC20, complete genomehypothetical protein2e-22104
NC_018515:989616:100353510035351003789255Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein9e-22102
NC_014377:1298806:131122213112221311482261Thermosediminibacter oceani DSM 16646 chromosome, complete genomeprotein of unknown function DUF9652e-21101
NC_012469:198096:216088216088216354267Streptococcus pneumoniae Taiwan19F-14, complete genomehypothetical protein2e-2097.8
NC_010380:254088:272100272100272366267Streptococcus pneumoniae Hungary19A-6, complete genomehypothetical protein2e-2097.8
NC_014251:440875:458300458300458566267Streptococcus pneumoniae TCH8431/19A chromosome, complete genomehypothetical protein2e-2097.8
NC_014328:1307490:131639313163931316644252Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein8e-2095.5
NC_021182:2422226:244371924437192443976258Clostridium pasteurianum BC1, complete genomehypothetical protein3e-1993.6
NC_017295:1809386:182917218291721829432261Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein4e-1993.6
NC_015687:1811573:183135918313591831619261Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein4e-1993.6
NC_003030:1811820:182975918297591830019261Clostridium acetobutylicum ATCC 824, complete genomehypothetical protein4e-1993.6
NC_009495:2685646:269953126995312699782252Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein6e-1992.8
NC_009699:2733529:274749527474952747746252Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein6e-1992.8
NC_008593:1461771:147075114707511471005255Clostridium novyi NT, complete genomeHypothetical UPF0297 protein8e-1992.4
NC_014098:1114076:111898011189801119246267Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF9655e-1889.7
NC_013895:35410:528135281353076264Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completehypothetical protein2e-1581.3
NC_011830:3786173:378719337871933787444252Desulfitobacterium hafniense DCB-2, complete genomeprotein of unknown function DUF9652e-1478.2