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Query: NC_007530:4176462:4182178 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 4182178, End: 4182816, Length: 639

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4191963:419267341926734193311639Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein5e-123439
NC_011969:4065460:406831340683134068951639Bacillus cereus Q1 chromosome, complete genomedimethyladenosine transferase5e-123439
NC_011658:4171237:417295341729534173591639Bacillus cereus AH187 chromosome, complete genomehypothetical protein5e-123439
NC_005957:4169610:417132641713264171964639Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein3e-122437
NC_014335:4113154:411386441138644114502639Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein9e-122435
NC_015275:4577642:4595596459559645971731578Clostridium lentocellum DSM 5427 chromosome, complete genomeCysteine synthase1e-39162
NC_000868:378130:389752389752390369618Pyrococcus abyssi GE5, complete genomemethlytransferase3e-26118
NC_016048:3947663:397372939737293974352624Oscillibacter valericigenes Sjm18-20, complete genomeputative methyltransferase6e-1580.9
NC_007681:696252:697984697984698661678Methanosphaera stadtmanae DSM 3091, complete genomehypothetical protein3e-0858.5
NC_007355:544796:558137558137558889753Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceubiquinone/menaquinone biosynthesis methyltransferase8e-0857
NC_015574:2322811:232662423266242327301678Methanobacterium sp. SWAN-1 chromosome, complete genometype 12 methyltransferase8e-0857
NC_013730:3137391:315058331505833151362780Spirosoma linguale DSM 74, complete genomeMethyltransferase type 111e-0756.2
NC_014624:2996377:300986630098663010609744Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein5e-0754.7
NC_017904:3113000:312282331228233123479657Mycobacterium sp. MOTT36Y chromosome, complete genomemethyltransferase6e-0754.3
NC_018681:1021063:104027410402741040933660Nocardia brasiliensis ATCC 700358 chromosome, complete genometype 11 methyltransferase1e-0653.1
NC_007604:1442500:145991414599141460555642Synechococcus elongatus PCC 7942, complete genomemembrane-associated protein1e-0653.1
NC_016641:1530905:154436315443631545133771Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein3e-0652
NC_015277:2702056:271979127197912720465675Sphingobacterium sp. 21 chromosome, complete genomeMethyltransferase type 125e-0651.2
NC_015573:110108:124628124628125548921Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genometype 11 methyltransferase5e-0651.2
NC_015572:1252000:128838412883841289139756Methylomonas methanica MC09 chromosome, complete genometype 11 methyltransferase6e-0650.8