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Query: NC_007530:3581202:3595657 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 3595657, End: 3595905, Length: 249

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008600:3611038:362235436223543622617264Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein2e-41167
NC_003997:3579972:359553035955303595778249Bacillus anthracis str. Ames, complete genomehypothetical protein2e-41167
NC_014335:3531931:354637935463793546627249Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-41167
NC_005957:3602744:361719936171993617447249Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-41167
NC_005945:3581776:359623135962313596479249Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-41167
NC_006274:3661194:367608236760823676330249Bacillus cereus E33L, complete genomehypothetical protein2e-41167
NC_011773:3615998:363045236304523630700249Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-41167
NC_012581:639329:642783642783643031249Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-41167
NC_012659:3579999:359555735955573595805249Bacillus anthracis str. A0248, complete genomehypothetical protein2e-41167
NC_016771:3520522:353609635360963536344249Bacillus cereus NC7401, complete genomehypothetical protein2e-41167
NC_017200:3622838:363729036372903637538249Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-41167
NC_011772:3705878:372396837239683724216249Bacillus cereus G9842, complete genomehypothetical protein2e-40164
NC_012472:3625800:364036136403613640609249Bacillus cereus 03BB102, complete genomehypothetical protein1e-40164
NC_014171:3661512:367959236795923679840249Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein6e-40162
NC_011725:3785769:380032938003293800577249Bacillus cereus B4264 chromosome, complete genomehypothetical protein6e-40162
NC_009253:3317533:333373433337343333997264Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein7e-0959.3
NC_021184:3793285:379533237953323795592261Desulfotomaculum gibsoniae DSM 7213, complete genomeProtein of unknown function (DUF3243)2e-0651.6