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Query: NC_007530:3581202:3594732 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 3594732, End: 3595517, Length: 786

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:3622838:363636536363653637150786Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein1e-152538
NC_003997:3579972:359460535946053595390786Bacillus anthracis str. Ames, complete genomeACT domain protein1e-152538
NC_005957:3602744:361627436162743617059786Bacillus thuringiensis serovar konkukian str. 97-27, completeconserved hypothetical protein, possible ACT domain protein1e-152538
NC_006274:3661194:367515736751573675942786Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible ACT domain protein1e-152538
NC_012472:3625800:363943636394363640221786Bacillus cereus 03BB102, complete genomeACT domain protein1e-152538
NC_008600:3611038:362142936214293622214786Bacillus thuringiensis str. Al Hakam, complete genomepossible ACT domain protein1e-152538
NC_011772:3705878:372304437230443723829786Bacillus cereus G9842, complete genomeACT domain protein1e-152538
NC_005945:3581776:359530635953063596091786Bacillus anthracis str. Sterne, complete genomeACT domain protein1e-152538
NC_014335:3531931:354545435454543546239786Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-152538
NC_011725:3785769:379940537994053800190786Bacillus cereus B4264 chromosome, complete genomeACT domain-containing protein1e-152538
NC_011773:3615998:362952736295273630312786Bacillus cereus AH820 chromosome, complete genomeACT domain-containing protein1e-152538
NC_012581:639329:643171643171643956786Bacillus anthracis str. CDC 684 chromosome, complete genomeACT domain-containing protein1e-152538
NC_012659:3579999:359463235946323595417786Bacillus anthracis str. A0248, complete genomeACT domain protein1e-152538
NC_014171:3661512:367866836786683679453786Bacillus thuringiensis BMB171 chromosome, complete genomeACT domain-containing protein1e-152538
NC_016771:3520522:353517135351713535956786Bacillus cereus NC7401, complete genomeACT domain-containing protein1e-152538
NC_011899:948790:948790948790949557768Halothermothrix orenii H 168, complete genomeamino acid-binding ACT domain protein9e-52203