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Query: NC_007530:1007140:1020828 Bacillus anthracis str. 'Ames Ancestor', complete genome

Start: 1020828, End: 1021235, Length: 408

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:991298:100255810025581002965408Bacillus cereus F837/76 chromosome, complete genomePadR family transcriptional regulator3e-73273
NC_012659:1008028:102072810207281021135408Bacillus anthracis str. A0248, complete genomelineage-specific thermal regulator protein3e-73273
NC_011773:1050000:106303310630331063440408Bacillus cereus AH820 chromosome, complete genomelineage-specific thermal regulator protein3e-73273
NC_005945:1008000:102072110207211021128408Bacillus anthracis str. Sterne, complete genomelineage-specific thermal regulator protein3e-73273
NC_003997:1007139:102082810208281021235408Bacillus anthracis str. Ames, complete genomelineage-specific thermal regulator protein3e-73273
NC_005957:1037205:105006310500631050470408Bacillus thuringiensis serovar konkukian str. 97-27, completelineage-specific thermal regulator protein3e-73273
NC_006274:1040836:105374410537441054151408Bacillus cereus E33L, complete genomelineage-specific thermal regulator protein8e-73271
NC_017200:1157835:117385811738581174265408Bacillus thuringiensis serovar finitimus YBT-020 chromosome,lineage-specific thermal regulator protein2e-69260
NC_011725:1032500:104585210458521046259408Bacillus cereus B4264 chromosome, complete genomelineage-specific thermal regulator protein3e-69259
NC_011969:1084000:109521610952161095623408Bacillus cereus Q1 chromosome, complete genomelineage-specific thermal regulator protein6e-69258
NC_011772:1011220:102207310220731022480408Bacillus cereus G9842, complete genometranscriptional regulator, PadR family1e-68257
NC_017208:1050414:106457910645791064986408Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePadR family transcriptional regulator9e-68254
NC_010184:1017000:102963310296331030040408Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, PadR-like family2e-64243
NC_015589:2019370:202883520288352029266432Desulfotomaculum ruminis DSM 2154 chromosome, complete genometranscriptional regulator PadR family protein5e-1269.7
NC_014393:4352216:437518143751814375525345Clostridium cellulovorans 743B chromosome, complete genometranscriptional regulator, PadR-like family4e-0753.5
NC_018704:1424728:142569314256931426040348Amphibacillus xylanus NBRC 15112, complete genomeputative PadR family transcriptional regulator1e-0651.6
NC_015216:1278706:131078813107881311147360Methanobacterium sp. AL-21 chromosome, complete genomePadR-like family transcriptional regulator1e-0651.6
NC_018664:2638102:264078026407802641118339Clostridium acidurici 9a chromosome, complete genometranscriptional regulator, PadR family3e-0650.8