Pre_GI: BLASTP Hits

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Query: NC_007384:307013:323274 Shigella sonnei Ss046, complete genome

Start: 323274, End: 324218, Length: 945

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010473:1384000:138894413889441389888945Escherichia coli str. K-12 substr. DH10B, complete genome2,3-dihydroxyphenylpropionate 1,2-dioxygenase0645
NC_014118:987889:100433310043331005277945Burkholderia sp. CCGE1002 chromosome chromosome 2, completeExtradiol ring-cleavage dioxygenase class III protein subunit B1e-95350
NC_008705:4053070:407402640740264074976951Mycobacterium sp. KMS, complete genomeExtradiol ring-cleavage dioxygenase, class III enzyme, subunit B2e-81302
NC_009921:3384116:340632134063213407262942Frankia sp. EAN1pec, complete genomeExtradiol ring-cleavage dioxygenase class III protein subunit B1e-76286
NC_008146:4019711:403954440395444040392849Mycobacterium sp. MCS, complete genomeExtradiol ring-cleavage dioxygenase, class III enzyme, subunit B4e-74278
NC_016948:2931285:297894629789462979857912Mycobacterium intracellulare MOTT-64 chromosome, complete genome3-(2,3-dihydroxyphenyl)propionate dioxygenase9e-34144
NC_008595:2687245:269157126915712692293723Mycobacterium avium 104, complete genomearomatic ring-opening dioxygenase, catalytic LigB subunit3e-25116
NC_015554:4002952:400954440095444010371828Alteromonas sp. SN2 chromosome, complete genomeprotocatechuate 4,5-dioxygenase subunit beta1e-1894
NC_014098:2332938:234623223462322347038807Bacillus tusciae DSM 2912 chromosome, complete genomeExtradiol ring-cleavage dioxygenase class III protein subunit B6e-1891.7
NC_010002:4175809:419400741940074194879873Delftia acidovorans SPH-1, complete genomeProtocatechuate 4,5-dioxygenase1e-1377.4
NC_015563:3401867:340186734018673402739873Delftia sp. Cs1-4 chromosome, complete genomeprotocatechuate 4,5-dioxygenase1e-1377
NC_002927:4392768:4395098439509843961321035Bordetella bronchiseptica RB50, complete genomeputative dioxygenase1e-1274.3
NC_016147:2964178:297445429744542975260807Pseudoxanthomonas spadix BD-a59 chromosome, complete genomeprotocatechuate 4,5-dioxygenase subunit beta4e-1272.4
NC_009376:446224:470685470685471515831Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeextradiol ring-cleavage dioxygenase III subunit B1e-0964.3
NC_013716:3327881:3326622332662233278841263Citrobacter rodentium ICC168, complete genomeputative extradiol dioxygenase2e-0860.1