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Query: NC_007384:2587876:2607855 Shigella sonnei Ss046, complete genome

Start: 2607855, End: 2608130, Length: 276

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016902:1419413:142642814264281426703276Escherichia coli KO11FL chromosome, complete genomehypothetical protein1e-38158
NC_010468:1412791:141611314161131416388276Escherichia coli ATCC 8739, complete genomehypothetical protein1e-38158
CP002185:2659628:267915426791542679429276Escherichia coli W, complete genomepredicted lipoprotein involved in colanic acid biosynthesis1e-38158
CP002516:1419413:142642814264281426703276Escherichia coli KO11, complete genomehypothetical protein1e-38158
CU928160:2513000:253160325316032531878276Escherichia coli IAI1 chromosome, complete genomeputative lipoprotein1e-38158
AP010958:2911741:294569229456922945967276Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted lipoprotein1e-38158
NC_011741:2513000:253160325316032531878276Escherichia coli IAI1 chromosome, complete genomehypothetical protein1e-38158
NC_012947:1363724:136704613670461367321276Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein1e-38158
NC_012967:2409500:242892224289222429197276Escherichia coli B str. REL606 chromosome, complete genomeputative lipoprotein involved in colanic acid biosynthesis1e-38158
NC_013353:2911741:294569229456922945967276Escherichia coli O103:H2 str. 12009, complete genomelipoprotein1e-38158
NC_007613:2376974:239662723966272396902276Shigella boydii Sb227, complete genomehypothetical protein2e-38157
NC_004741:2456297:247588824758882476163276Shigella flexneri 2a str. 2457T, complete genomehypothetical protein3e-38156
NC_017328:2516000:253539225353922535667276Shigella flexneri 2002017 chromosome, complete genomehypothetical protein3e-38156
NC_011601:2614691:265110626511062651381276Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomelipoprotein involved in colanic acid biosynthesis1e-35148
NC_008253:2499735:251812625181262518401276Escherichia coli 536, complete genomehypothetical lipoprotein YpdI precursor1e-35148
NC_011745:2751437:276943627694362769711276Escherichia coli ED1a chromosome, complete genomeputative lipoprotein7e-35145
NC_008563:2610499:262850226285022628777276Escherichia coli APEC O1, complete genomeputative lipoprotein involved in colanic acid biosynthesis7e-34142
NC_013941:2928000:296394929639492964176228Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein1e-32138
NC_007606:2353098:237192423719242372199276Shigella dysenteriae Sd197, complete genomehypothetical protein8e-27119