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Query: NC_007323:1:8210 Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, complete

Start: 8210, End: 11068, Length: 2859

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007323:81837:82108210110682859Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, completemembrane protein, putative, (pxo2-14)01714
NC_014332:1:91159115120722958Bacillus cereus biovar anthracis str. CI plasmid pCI-XO2, completehypothetical protein01629
NC_006578:1:80818081114463366Bacillus thuringiensis serovar konkukian str. 97-27 plasmidpossible membrane protein0878
NC_020995:477765:4860794860794887542676Enterococcus casseliflavus EC20, complete genomehypothetical protein9e-62239
NC_010999:561914:5887385887385907952058Lactobacillus casei, complete genomePutative uncharacterized protein2e-0862