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Query: NC_007322:57710:75545 Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, complete

Start: 75545, End: 76477, Length: 933

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012656:67949:758097580976741933Bacillus anthracis str. A0248 plasmid pXO1, complete sequencehypothetical protein4e-150530
NC_012579:72715:758537585376785933Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein7e-150530
NC_014331:57769:755717557176503933Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completemembrane protein3e-149527
NC_017203:73952:111793111793112725933Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,membrane protein2e-145515
NC_012473:46000:601396013961071933Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein5e-145513
NC_011775:185409:188517188517189500984Bacillus cereus G9842 plasmid pG9842_209, complete sequenceconserved membrane protein, putative2e-34146