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Query: NC_006369:734080 Legionella pneumophila str. Lens, complete genome

Start: 734080, End: 770177, Length: 36098

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_006368:75035675035678452334168Legionella pneumophila str. Paris, complete genome07297BLASTN svgBLASTP svg
NC_002942:675829*67582969929423466Legionella pneumophila subsp. pneumophila str. Philadelphia 1,05227BLASTN svgBLASTP svg
NC_009465:766893*76689380098034088Candidatus Vesicomyosocius okutanii HA, complete genome8e-1797.6BLASTN svgBLASTP svg
NC_013861:72864872864875231223665Legionella longbeachae NSW150, complete genome5e-1281.8BLASTN svgBLASTP svg
NC_015722:4539*45393359929061Candidatus Midichloria mitochondrii IricVA chromosome, complete1e-0973.8BLASTN svgBLASTP svg
NC_014315:352395*35239537271520321Nitrosococcus watsoni C-113 chromosome, complete genome4e-0971.9BLASTN svgBLASTP svg