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Query: NC_006369:734080:763740 Legionella pneumophila str. Lens, complete genome

Start: 763740, End: 764090, Length: 351

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006368:750356:778084778084778434351Legionella pneumophila str. Paris, complete genomehypothetical protein9e-62234
NC_014125:766576:787114787114787332219Legionella pneumophila 2300/99 Alcoy chromosome, complete genomemultidrug efflux protein2e-34144
NC_009494:775676:801075801075801293219Legionella pneumophila str. Corby chromosome, complete genomehypothetical protein2e-34144
NC_011901:2466360:247126724712672471692426Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein3e-28123
NC_008702:3375027:337684833768483377219372Azoarcus sp. BH72, complete genomeconserved hypothetical protein6e-2199.4
NC_007484:2045500:2046956204695620495052550Nitrosococcus oceani ATCC 19707, complete genomehypothetical protein5e-2096.7
NC_014221:2943950:2953689295368929568863198Truepera radiovictrix DSM 17093 chromosome, complete genomeprotein of unknown function DUF5599e-1992
NC_014313:3617910:370237024091390Hyphomicrobium denitrificans ATCC 51888 chromosome, completeprotein of unknown function DUF5593e-1787.4
NC_019904:3072241:308520730852073085575369Echinicola vietnamensis DSM 17526 chromosome, complete genomehypothetical protein4e-1580.1
NC_008571:365047:3828973828973860373141Gramella forsetii KT0803, complete genome5-methyltetrahydrofolate:homocysteine methyltran sferase-cobalamin binding domain2e-1477.4
NC_002939:1480474:149751214975121498039528Geobacter sulfurreducens PCA, complete genomehypothetical protein2e-1477.4
NC_015696:285456:296447296447296827381Francisella sp. TX077308 chromosome, complete genomeDNA methylase2e-1477.4
NC_015633:461143:485740485740486096357Vibrio anguillarum 775 chromosome chromosome I, complete sequencehypothetical protein4e-1476.6
NC_008245:529378:547003547003547389387Francisella tularensis subsp. tularensis FSC 198, complete genomehypothetical protein7e-1372.8
NC_006570:529426:547051547051547437387Francisella tularensis subsp. tularensis Schu 4, complete genomehypothetical protein7e-1372.8
NC_016933:608889:622980622980623366387Francisella tularensis TIGB03 chromosome, complete genomeDNA methylase putative7e-1372.8
NC_016937:529459:547073547073547459387Francisella tularensis subsp. tularensis TI0902 chromosome,DNA methylase putative7e-1372.8
NC_009257:963536:966722966722967108387Francisella tularensis subsp. tularensis WY96-3418 chromosome,hypothetical protein6e-1372.8
NC_008369:939356:952207952207952593387Francisella tularensis subsp. holarctica OSU18, complete genomehypothetical protein5e-1372.8
NC_009749:937412:950264950264950650387Francisella tularensis subsp. holarctica FTA, complete genomehypothetical protein5e-1372.8
NC_007880:935670:948522948522948908387Francisella tularensis subsp. holarctica, complete genomehypothetical protein5e-1372.8
NC_019960:1362370:136185313618531362383531Prevotella dentalis DSM 3688 chromosome 1, complete sequencehypothetical protein2e-1064.3
NC_020156:49666:705407054070791252Nonlabens dokdonensis DSW-6, complete genometype I site-specific deoxyribonuclease, HsdR family3e-1063.5
NC_013204:3613824:362783136278313628232402Eggerthella lenta DSM 2243, complete genomeprotein of unknown function DUF5597e-0959.3
NC_016077:998741:105819010581901058579390Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein4e-0857
NC_016077:998741:105982610598261060215390Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein8e-0855.8