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Query: NC_006369:3058000:3062132 Legionella pneumophila str. Lens, complete genome

Start: 3062132, End: 3063223, Length: 1092

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008344:950241:9634409634409645401101Nitrosomonas eutropha C91, complete genomeputative membrane-bound dehydrogenase oxidoreductase protein1e-114413
NC_010682:288415:3068933068933081521260Ralstonia pickettii 12J chromosome 1, complete sequenceputative glucose/sorbosone dehydrogenase5e-63241
NC_014315:3207684:3222196322219632233861191Nitrosococcus watsoni C-113 chromosome, complete genomeoxidoreductase2e-62239
NC_006156:17637:2266822668238071140Borrelia garinii PBi chromosome linear, complete sequencehypothetical protein4e-62238
NC_007484:3358000:3371908337190833731041197Nitrosococcus oceani ATCC 19707, complete genomeoxidoreductase, putative6e-62238
NC_009441:3155500:3163106316310631642721167Flavobacterium johnsoniae UW101 chromosome, complete genomeglucose/sorbosone dehydrogenase-like protein2e-40167
NC_010170:4800000:4906147490614749074301284Bordetella petrii, complete genomeL-sorbosone dehydrogenase4e-36152
NC_014623:7133149:7141182714118271424951314Stigmatella aurantiaca DW4/3-1 chromosome, complete genomel-sorbosone dehydrogenase1e-34147
NC_011071:4235830:4260170426017042614801311Stenotrophomonas maltophilia R551-3, complete genomeL-sorbosone dehydrogenase2e-34146
NC_004757:2730057:2733973273397327353071335Nitrosomonas europaea ATCC 19718, complete genomeL-sorbosone dehydrogenase5e-34145
NC_014623:9552:2014520145214401296Stigmatella aurantiaca DW4/3-1 chromosome, complete genomel-sorbosone dehydrogenase7e-34144
NC_005125:3446470:3471014347101434729691956Gloeobacter violaceus PCC 7421, complete genomeprobable L-sorbosone dehydrogenase1e-32140
NC_009338:686932:7146547146547159851332Mycobacterium gilvum PYR-GCK chromosome, complete genomeSMP-30/gluconolaconase/LRE-like region1e-30134
NC_014814:132404:1324041324041337351332Mycobacterium sp. Spyr1 chromosome, complete genomeglucose/sorbosone dehydrogenase1e-30134
NC_016631:1117241:1120546112054611219971452Granulicella mallensis MP5ACTX8 chromosome, complete genomeNHL repeat-containing protein9e-29127
NC_016112:2903767:2907458290745829086091152Methylomicrobium alcaliphilum chromosome, complete genomeL-sorbosone dehydrogenase5e-25115
NC_013959:2449315:2452866245286624540951230Sideroxydans lithotrophicus ES-1 chromosome, complete genomeglucose/sorbosone dehydrogenase-like protein7e-23108
NC_013524:171524:1947631947631960371275Sphaerobacter thermophilus DSM 20745 chromosome 2, complete genomeQuinoprotein glucose dehydrogenase2e-0757.4