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Query: NC_006369:2888701:2905266 Legionella pneumophila str. Lens, complete genome

Start: 2905266, End: 2905946, Length: 681

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016811:2903871:292159829215982922278681Legionella pneumophila subsp. pneumophila ATCC 43290 chromosome,acid phosphatase, class B8e-116416
NC_014125:3054000:307172930717293072409681Legionella pneumophila 2300/99 Alcoy chromosome, complete genomehypothetical protein8e-116416
NC_002942:2943206:296093329609332961613681Legionella pneumophila subsp. pneumophila str. Philadelphia 1,acid phosphatase, class B8e-116416
NC_009494:3119997:313772431377243138404681Legionella pneumophila str. Corby chromosome, complete genomeacid phosphatase3e-115414
NC_011894:3090000:309130630913063092040735Methylobacterium nodulans ORS 2060, complete genomeacid phosphatase (Class B)6e-31134
NC_006570:141966:171934171934172518585Francisella tularensis subsp. tularensis Schu 4, complete genomeacid phosphatase5e-21101
NC_008245:141982:171950171950172534585Francisella tularensis subsp. tularensis FSC 198, complete genomeacid phosphatase5e-21101
NC_010677:214712:244554244554245138585Francisella tularensis subsp. mediasiatica FSC147, complete genomeacid phosphatase, HAD superfamily protein5e-21101
NC_009257:226417:256385256385256969585Francisella tularensis subsp. tularensis WY96-3418 chromosome,acid phosphatase5e-21101
NC_016933:141984:171952171952172536585Francisella tularensis TIGB03 chromosome, complete genomeAcid phosphatase class B5e-21101
NC_016937:141984:171952171952172536585Francisella tularensis subsp. tularensis TI0902 chromosome,Acid phosphatase class B5e-21101
NC_014218:696409:7014377014377033201884Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomeLPXTG-motif cell wall anchor domain protein4e-1788.2
NC_020291:1810527:182642818264281827258831Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome5'-nucleotidase, lipoprotein e(P4) family4e-0651.6