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Query: NC_006369:2888701:2900813 Legionella pneumophila str. Lens, complete genome

Start: 2900813, End: 2901592, Length: 780

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016811:2903871:291714529171452917924780Legionella pneumophila subsp. pneumophila ATCC 43290 chromosome,cell division protein ZipA7e-130462
NC_009494:3119997:313327131332713134050780Legionella pneumophila str. Corby chromosome, complete genomecell division protein ZipA7e-130462
NC_002942:2943206:295648029564802957259780Legionella pneumophila subsp. pneumophila str. Philadelphia 1,cell division protein ZipA7e-130462
NC_014125:3054000:306727630672763068055780Legionella pneumophila 2300/99 Alcoy chromosome, complete genomecell division protein ZipA2e-129461
NC_006368:3028286:304374030437403044519780Legionella pneumophila str. Paris, complete genomehypothetical protein3e-129461
NC_013861:3215640:323386532338653234677813Legionella longbeachae NSW150, complete genomecell division protein9e-76283
NC_008027:1847040:185139718513971852281885Pseudomonas entomophila L48, complete genomecell division protein ZipA2e-2099.4
NC_010501:3987615:400821340082134009097885Pseudomonas putida W619, complete genomecell division protein ZipA2e-1996.7
NC_020829:3434736:345131334513133452200888Pseudomonas denitrificans ATCC 13867, complete genomecell division protein ZipA7e-1994.4
NC_009434:2006500:200658420065842007405822Pseudomonas stutzeri A1501, complete genomecell division protein ZipA2e-1893.2
NC_015740:1845370:184537018453701846191822Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completecell division protein ZipA4e-1892
NC_016745:2913712:2932974293297429339961023Oceanimonas sp. GK1 chromosome, complete genomecell division protein ZipA2e-1685.9
NC_009654:3849774:3851894385189438529221029Marinomonas sp. MWYL1, complete genomecell division protein ZipA5e-1684.7
NC_013716:2476334:249268924926892493684996Citrobacter rodentium ICC168, complete genomecell division protein1e-1377
NC_020541:1786500:182413118241311825111981Rhodanobacter sp. 2APBS1, complete genomecell division protein ZipA7e-1064.7