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Query: NC_006368:2684358 Legionella pneumophila str. Paris, complete genome

Start: 2684358, End: 2712755, Length: 28398

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain is endemic in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_002942:11096181109618113209922482Legionella pneumophila subsp. pneumophila str. Philadelphia 1,022880BLASTN svgBLASTP svg
NC_009727:766000*76600078929223293Coxiella burnetii Dugway 7E9-12, complete genome2e-56228BLASTN svgBLASTP svg
NC_015638:328601*32860134893320333Lacinutrix sp. 5H-3-7-4 chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_011992:22797522279752232691047159Acidovorax ebreus TPSY, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014972:13718413718416221025027Desulfobulbus propionicus DSM 2032 chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015277:93571*9357111870825138Sphingobacterium sp. 21 chromosome, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_010501:30000300007042840429Pseudomonas putida W619, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_009512:27783277836731639534Pseudomonas putida F1, complete genome8e-0763.9BLASTN svgBLASTP svg