Pre_GI: BLASTP Hits

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Query: NC_006085:925604:948169 Propionibacterium acnes KPA171202, complete genome

Start: 948169, End: 948480, Length: 312

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:1700000:170982017098201710650831Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-38156
NC_009699:1698951:170968917096891710519831Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-38156
NC_012658:1658505:166887916688791669709831Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein4e-38156
NC_013406:5954472:595447259544725955302831Paenibacillus sp. Y412MC10 chromosome, complete genomeTIM-barrel signal transduction protein1e-37154
NC_008593:1859861:187885718788571879687831Clostridium novyi NT, complete genomehypothetical protein2e-36150
NC_014328:2518081:252199425219942522824831Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein4e-35146
NC_019974:3013338:304235130423513043184834Natronococcus occultus SP4, complete genomeputative TIM-barrel enzyme, possibly a dioxygenase4e-34143
NC_014298:310964:329305329305330138834Halalkalicoccus jeotgali B3 plasmid 1, complete sequenceTIM-barrel signal transduction protein7e-34142
NC_017297:1700000:1707235170723517084221188Clostridium botulinum F str. 230613 chromosome, complete genomeAraC family transcriptional regulator4e-2096.7
NC_012658:1658505:1666264166626416674811218Clostridium botulinum Ba4 str. 657 chromosome, complete genomeAraC family transcriptional regulator4e-2096.7
NC_009699:1698951:1707074170707417082911218Clostridium botulinum F str. Langeland chromosome, complete genomeAraC family transcriptional regulator4e-2096.7
NC_014328:2518081:2524207252420725254541248Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator1e-1995.1
NC_013406:5954472:5956693595669359579341242Paenibacillus sp. Y412MC10 chromosome, complete genomeAraC family transcriptional regulator5e-1786.3
NC_008593:1859861:1881113188111318822881176Clostridium novyi NT, complete genometranscriptional regulator, araC family protein4e-1476.6