Pre_GI: BLASTP Hits

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Query: NC_005956:818000:834095 Bartonella henselae str. Houston-1, complete genome

Start: 834095, End: 834499, Length: 405

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005956:818000:832306832306832722417Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein1e-49194
NC_010161:432000:470978470978471385408Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-47188
NC_010161:432000:467210467210467617408Bartonella tribocorum CIP 105476, complete genomehypothetical protein3e-46183
NC_010161:432000:469079469079469492414Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-44177
NC_010161:432000:472847472847473260414Bartonella tribocorum CIP 105476, complete genomehypothetical protein7e-44175
NC_005956:818000:832700832700833320621Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein7e-44175
NC_005956:818000:833501833501833914414Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein2e-42170
NC_005956:818000:837451837451837855405Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein2e-40164
NC_010161:432000:474780474780475193414Bartonella tribocorum CIP 105476, complete genomehypothetical protein3e-37153
NC_012846:929570:945310945310945717408Bartonella grahamii as4aup, complete genomehypothetical protein6e-32135
NC_005956:818000:835294835294835701408Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein7e-27119
NC_005956:818000:834681834681835130450Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein1e-0755.5