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Query: NC_005956:818000:818447 Bartonella henselae str. Houston-1, complete genome

Start: 818447, End: 818716, Length: 270

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014722:846084:859847859847860146300Burkholderia rhizoxinica HKI 454, complete genomeRelB protein1e-0962
NC_014722:1497244:150861815086181508887270Burkholderia rhizoxinica HKI 454, complete genomeRelB protein1e-1065.1
NC_010803:1436397:143779014377901438038249Chlorobium limicola DSM 245, complete genomeCopG domain protein DNA-binding domain protein3e-1167
NC_008639:1573971:157397115739711574195225Chlorobium phaeobacteroides DSM 266, complete genomeCopG domain protein DNA-binding domain protein8e-1165.9
NC_013422:1755875:176336517633651763589225Halothiobacillus neapolitanus c2, complete genomeCopG domain protein DNA-binding domain protein2e-0858.2
NC_013960:2592389:260072526007252600949225Nitrosococcus halophilus Nc4 chromosome, complete genomeCopG domain protein DNA-binding domain protein2e-0754.7
NC_011059:2272747:227636922763692276617249Prosthecochloris aestuarii DSM 271, complete genomeCopG domain protein DNA-binding domain protein7e-1269.3
NC_011901:3363500:337984133798413380068228Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein1e-0755.5