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Query: NC_005956:1888500:1895012 Bartonella henselae str. Houston-1, complete genome

Start: 1895012, End: 1895293, Length: 282

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005955:1540838:154724915472491547530282Bartonella quintana str. Toulouse, complete genomepH adaptation potassium efflux system f3e-35146
NC_012846:2299282:230568923056892305970282Bartonella grahamii as4aup, complete genomemulticomponent K+:H+ antiporter subunit F4e-35146
NC_008783:29972:412604126041541282Bartonella bacilliformis KC583, complete genomepH adaptation potassium efflux system protein F2e-31134
NC_010725:5491491:551608455160845516368285Methylobacterium populi BJ001, complete genomemultiple resistance and pH regulation protein F3e-1993.6
NC_004578:3921199:392335739233573923635279Pseudomonas syringae pv. tomato str. DC3000, complete genomepotassium efflux system protein PhaF1e-1478.6
NC_015276:565701:572619572619572888270Marinomonas mediterranea MMB-1 chromosome, complete genomemultiple resistance and pH regulation protein F7e-1475.9
NC_016041:2420098:242850724285072428776270Glaciecola nitratireducens FR1064 chromosome, complete genomeputative monovalent cation/H+ antiporter subunit F3e-1167
NC_008260:2992813:299939229993922999661270Alcanivorax borkumensis SK2, complete genomeMultisubunit Na+/H+ antiporter, MnhF subunit1e-1064.7
NC_019940:1963000:197928119792811979553273Thioflavicoccus mobilis 8321 chromosome, complete genomemultisubunit Na+/H+ antiporter subunit MnhF5e-1063.2
NC_006322:3198829:320395332039533204237285Bacillus licheniformis ATCC 14580, complete genomeMrpF1e-0651.6
NC_014225:1403007:141408314140831414376294Waddlia chondrophila WSU 86-1044 chromosome, complete genomemultiple resistance and pH homeostasis system, subunit F7e-0649.3