Pre_GI: BLASTP Hits

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Query: NC_005956:1888500:1893782 Bartonella henselae str. Houston-1, complete genome

Start: 1893782, End: 1894177, Length: 396

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005955:1540838:154600815460081546403396Bartonella quintana str. Toulouse, complete genomehypothetical protein7e-44175
NC_012846:2299282:230446323044632304858396Bartonella grahamii as4aup, complete genomehypothetical protein5e-40162
NC_005956:1888500:189419518941951894587393Bartonella henselae str. Houston-1, complete genomehypothetical protein2e-30130
NC_005955:1540838:154642315464231546815393Bartonella quintana str. Toulouse, complete genomehypothetical protein2e-27121
NC_008783:29972:419624196242354393Bartonella bacilliformis KC583, complete genomehypothetical protein3e-27120
NC_012846:2299282:230487623048762305265390Bartonella grahamii as4aup, complete genomehypothetical protein5e-22102