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Query: NC_005956:1572500:1593642 Bartonella henselae str. Houston-1, complete genome

Start: 1593642, End: 1594025, Length: 384

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020301:1486695:150882615088261509209384Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein1e-36151
NC_012846:1888000:190867319086731909038366Bartonella grahamii as4aup, complete genomehypothetical protein3e-36150
NC_014932:1232346:130579513057951306088294Bartonella clarridgeiae 73, complete genomehypothetical protein1e-28124
NC_020300:1344453:136382613638261364092267Bartonella australis Aust/NH1, complete genomehypothetical protein5e-25112