Pre_GI: BLASTP Hits

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Query: NC_005956:1572500:1576364 Bartonella henselae str. Houston-1, complete genome

Start: 1576364, End: 1577572, Length: 1209

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005956:1402500:1406355140635514075631209Bartonella henselae str. Houston-1, complete genome0759
NC_003296:612000:6190776190776203001224Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completehypothetical protein8e-71267
NC_010552:2131021:2141670214167021429081239Burkholderia ambifaria MC40-6 chromosome 2, complete sequencehypothetical protein7e-66251