Pre_GI: BLASTP Hits

Some Help

Query: NC_005956:1572500:1575135 Bartonella henselae str. Houston-1, complete genome

Start: 1575135, End: 1576232, Length: 1098

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005956:1402500:1405126140512614062231098Bartonella henselae str. Houston-1, complete genome0705
NC_003296:612000:6218916218916230901200Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completePUTATIVE TRANSPORT TRANSMEMBRANE PROTEIN7e-35148
NC_010552:2131021:2138886213888621400851200Burkholderia ambifaria MC40-6 chromosome 2, complete sequencemajor facilitator superfamily MFS_13e-32139