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Query: NC_005945:674337:688776 Bacillus anthracis str. Sterne, complete genome

Start: 688776, End: 691175, Length: 2400

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:678289:6887816887816911802400Bacillus anthracis str. A0248, complete genomeimmune inhibitor A metalloprotease01592
NC_003997:674265:6888806888806912792400Bacillus anthracis str. Ames, complete genomeimmune inhibitor A metalloprotease01592
NC_007530:674265:6888816888816912802400Bacillus anthracis str. 'Ames Ancestor', complete genomeimmune inhibitor a metalloprotease01592
NC_016779:657568:6702916702916726902400Bacillus cereus F837/76 chromosome, complete genomeImmune inhibitor A, metalloprotease01588
NC_011773:688689:7033197033197057182400Bacillus cereus AH820 chromosome, complete genomeimmune inhibitor A metalloprotease01588
NC_006274:659922:6772146772146796132400Bacillus cereus E33L, complete genomeimmune inhibitor A, metalloprotease01587
NC_005957:667954:6797646797646821632400Bacillus thuringiensis serovar konkukian str. 97-27, completeimmune inhibitor A, metalloprotease01585
NC_016771:701909:7165457165457189442400Bacillus cereus NC7401, complete genomeimmune inhibitor A metalloprotease01576
NC_011969:726369:7381847381847405832400Bacillus cereus Q1 chromosome, complete genomeimmune inhibitor a, metalloprotease01571
NC_011725:681387:6928156928156952142400Bacillus cereus B4264 chromosome, complete genomeimmune inhibitor A metalloprotease01543
NC_017208:671128:6848936848936872922400Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeimmune inhibitor A precursor01542
NC_004722:650950:6623776623776647762400Bacillus cereus ATCC 14579, complete genomeImmune inhibitor A precursor01541
NC_011772:647778:6607236607236631222400Bacillus cereus G9842, complete genomeimmune inhibitor A metalloprotease01538
NC_010184:661226:6739306739306763202391Bacillus weihenstephanensis KBAB4, complete genomepeptidase M6 immune inhibitor A01500
NC_011773:1277606:1305990130599013083772388Bacillus cereus AH820 chromosome, complete genomeimmune inhibitor A metalloprotease InhA101091
NC_014391:421547:4280514280514304682418Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeM6 family metalloprotease domain-containing protein5e-67256
NC_015588:2939747:2958554295855429608692316Isoptericola variabilis 225 chromosome, complete genomeM6 family metalloprotease domain protein2e-62241
NC_014391:421547:4308104308104336022793Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeM6 family metalloprotease domain-containing protein2e-51204
NC_004605:741000:7445507445507476123063Vibrio parahaemolyticus RIMD 2210633 chromosome II, completehypothetical protein2e-0861.6
NC_014966:638355:6418456418456457053861Vibrio vulnificus MO6-24/O chromosome II, complete sequencehypothetical protein1e-0655.8
NC_005140:660305:6637946637946676543861Vibrio vulnificus YJ016 chromosome II, complete sequencehypothetical protein4e-0653.9
NC_004460:81687:8528785287890363750Vibrio vulnificus CMCP6 chromosome II, complete sequencehypothetical protein4e-0653.9