Pre_GI: BLASTP Hits

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Query: NC_005945:5011857:5014555 Bacillus anthracis str. Sterne, complete genome

Start: 5014555, End: 5014953, Length: 399

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:5006219:501324650132465013644399Bacillus anthracis str. A0248, complete genomestage III sporulation protein D2e-72270
NC_007530:5006319:501334650133465013744399Bacillus anthracis str. 'Ames Ancestor', complete genomestage iii sporulation protein d2e-72270
NC_003997:5006193:501322050132205013618399Bacillus anthracis str. Ames, complete genomestage III sporulation protein D2e-72270
NC_013791:1323903:133805913380591338346288Bacillus pseudofirmus OF4 chromosome, complete genomestage III sporulation protein D6e-39159
NC_014829:4346500:436030243603024360586285Bacillus cellulosilyticus DSM 2522 chromosome, complete genomesporulation transcriptional regulator SpoIIID2e-38157
NC_012581:5008749:501577650157765015982207Bacillus anthracis str. CDC 684 chromosome, complete genomestage III sporulation protein D1e-32138
NC_009495:183767:196993196993197247255Clostridium botulinum A str. ATCC 3502 chromosome, complete genomestage III sporulation protein D5e-24109
NC_021182:4427468:443813744381374438391255Clostridium pasteurianum BC1, complete genomesporulation transcriptional regulator SpoIIID1e-22105
NC_003366:2494907:250339325033932503644252Clostridium perfringens str. 13, complete genomestage III sporulation protein D1e-22105
NC_008262:2379144:238397123839712384222252Clostridium perfringens SM101, complete genomestage III sporulation protein D1e-22105
NC_008261:2708929:271741327174132717664252Clostridium perfringens ATCC 13124, complete genomestage III sporulation protein D1e-22105
NC_019970:2531500:253828425382842538535252Thermoanaerobacterium thermosaccharolyticum M0795, complete genomesporulation transcriptional regulator SpoIIID7e-23105
NC_014410:2511753:252476425247642525015252Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,sporulation transcriptional regulator SpoIIID7e-23105
NC_015555:2259500:226646422664642266715252Thermoanaerobacterium xylanolyticum LX-11 chromosome, completesporulation transcriptional regulator SpoIIID2e-22104
NC_009922:2721343:275587327558732756130258Alkaliphilus oremlandii OhILAs, complete genomeSporulation stage III transcriptional regulator SpoIIID3e-22103
NC_015565:2736500:276596527659652766216252Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completesporulation transcriptional regulator SpoIIID4e-22103
NC_018664:201487:215995215995216252258Clostridium acidurici 9a chromosome, complete genomestage III sporulation protein D1e-21102
NC_015589:3711821:375195637519563752207252Desulfotomaculum ruminis DSM 2154 chromosome, complete genomesporulation transcriptional regulator SpoIIID1e-21101
NC_010723:485874:498791498791499045255Clostridium botulinum E3 str. Alaska E43, complete genomesporulation transcriptional regulator spoiiid2e-21100
NC_020291:684500:697652697652697906255Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomestage III sporulation protein D5e-2199.8
NC_014376:386650:406205406205406477273Clostridium saccharolyticum WM1 chromosome, complete genomesporulation transcriptional regulator SpoIIID2e-1994
NC_015977:2807782:284132428413242841551228Roseburia hominis A2-183 chromosome, complete genomesporulation transcriptional regulator SpoIIID1e-1891.7