Pre_GI: BLASTP Hits

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Query: NC_005945:4670978:4672957 Bacillus anthracis str. Sterne, complete genome

Start: 4672957, End: 4673670, Length: 714

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014829:1376253:139443613944361395095660Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeDNA alkylation repair enzyme2e-46186
NC_017316:2466244:246764024676402468341702Enterococcus faecalis OG1RF chromosome, complete genomeDNA alkylation repair protein4e-26118
NC_011969:4613430:461401546140154614728714Bacillus cereus Q1 chromosome, complete genomeDNA alkylation repair protein9e-132469
NC_016779:4645155:464574146457414646454714Bacillus cereus F837/76 chromosome, complete genomeDNA alkylation repair protein1e-135481
NC_014335:4622500:462309346230934623806714Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein6e-136483
NC_006274:4742489:474307447430744743787714Bacillus cereus E33L, complete genomehypothetical protein1e-133475
NC_017249:3229500:324699132469913247455465Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein2e-0652.8
NC_011773:4732457:473304347330434733756714Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-136484
NC_012472:4691251:469183746918374692550714Bacillus cereus 03BB102, complete genomehypothetical protein1e-135481
NC_004668:2938000:293953529395352940188654Enterococcus faecalis V583, complete genomehypothetical protein3e-26119
NC_003901:678340:692531692531693250720Methanosarcina mazei Go1, complete genomehypothetical protein1e-0860.5
NC_011658:4672000:467260446726044673317714Bacillus cereus AH187 chromosome, complete genomehypothetical protein8e-132469
NC_004369:1051013:107071610707161071336621Corynebacterium efficiens YS-314, complete genomehypothetical protein8e-32137
NC_003888:1395319:139750813975081398413906Streptomyces coelicolor A3(2), complete genomehypothetical protein6e-1787.8
NC_008600:4687500:468803446880344688831798Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein8e-136482
NC_017200:4697500:469760946976094698322714Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-133474
NC_015558:1425271:145278114527811453446666Streptococcus parauberis KCTC 11537 chromosome, complete genomehypothetical protein7e-33140
NC_016048:4163225:416873541687354169136402Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein7e-2097.4