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Query: NC_005945:4670978:4672371 Bacillus anthracis str. Sterne, complete genome

Start: 4672371, End: 4672838, Length: 468

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:4645155:464515546451554645622468Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-74277
NC_011773:4732457:473245747324574732924468Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-74277
NC_011658:4672000:467201946720194672486468Bacillus cereus AH187 chromosome, complete genomehypothetical protein1e-74277
NC_012472:4691251:469125146912514691718468Bacillus cereus 03BB102, complete genomehypothetical protein1e-74277
NC_014335:4622500:462250846225084622975468Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-74277
NC_006274:4742489:474248947424894742956468Bacillus cereus E33L, complete genomegroup-specific protein1e-74277
NC_011969:4613430:461343046134304613897468Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-74276