Pre_GI: BLASTP Hits

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Query: NC_005945:4473790:4490680 Bacillus anthracis str. Sterne, complete genome

Start: 4490680, End: 4491492, Length: 813

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449001844900184490851834Bacillus anthracis str. A0248, complete genomehypothetical protein3e-158557
NC_012581:4478036:449154244915424492375834Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein3e-158557
NC_003997:4473973:448999144899914490803813Bacillus anthracis str. Ames, complete genomehypothetical protein3e-158557
NC_007530:4474000:449011844901184490930813Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein3e-158557
NC_005957:4472800:448507044850704485882813Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-157554
NC_011773:4541306:455349945534994554311813Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-157554
NC_017200:4484399:450026845002684501080813Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein6e-157553
NC_011969:4396000:441240744124074413219813Bacillus cereus Q1 chromosome, complete genomehypothetical protein6e-157553
NC_017208:4662500:467453146745314675343813Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-155548
NC_011772:4606000:461950246195024620314813Bacillus cereus G9842, complete genomehypothetical protein4e-155547
NC_011725:4636521:465365246536524654485834Bacillus cereus B4264 chromosome, complete genomehypothetical protein1e-154545
NC_010184:4497473:451470745147074515519813Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF14446e-153540
NC_004722:4614442:462937946293794630170792Bacillus cereus ATCC 14579, complete genomehypothetical Cytosolic Protein2e-150531
NC_014335:4414052:442394444239444424438495Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-92338
NC_017353:1235095:124237512423751243235861Staphylococcus lugdunensis N920143, complete genomehypothetical protein3e-77288
NC_013959:1059004:109545310954531096301849Sideroxydans lithotrophicus ES-1 chromosome, complete genomehypothetical protein1e-0757.4
NC_014008:3500000:350737135073713508009639Coraliomargarita akajimensis DSM 45221 chromosome, complete genomehypothetical protein3e-0652.4