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Query: NC_005945:4116978:4122122 Bacillus anthracis str. Sterne, complete genome

Start: 4122122, End: 4122415, Length: 294

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:4039103:404378040437804044073294Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-39161
NC_007530:4117071:412174841217484122041294Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-39161
NC_003909:4064904:407016740701674070535369Bacillus cereus ATCC 10987, complete genomehypothetical protein1e-39161
NC_005957:4104880:410955741095574109850294Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-39161
NC_012472:4119192:412608241260824126375294Bacillus cereus 03BB102, complete genomesporulation protein YqfC1e-39161
NC_003997:4116944:412162141216214121914294Bacillus anthracis str. Ames, complete genomehypothetical protein1e-39161
NC_011658:4107501:411451141145114114804294Bacillus cereus AH187 chromosome, complete genomesporulation protein YqfC1e-39161
NC_011773:4108855:411353241135324113825294Bacillus cereus AH820 chromosome, complete genomesporulation protein YqfC1e-39161
NC_012581:4118366:412304341230434123336294Bacillus anthracis str. CDC 684 chromosome, complete genomesporulation protein YqfC1e-39161
NC_012659:4116971:412164841216484121941294Bacillus anthracis str. A0248, complete genomesporulation protein YqfC1e-39161
NC_016771:4059445:406829540682954068588294Bacillus cereus NC7401, complete genomehypothetical protein1e-39161
NC_006274:4159096:416377341637734164066294Bacillus cereus E33L, complete genomehypothetical protein3e-39160
NC_014335:4027105:403178240317824032075294Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein3e-39160
NC_010184:4155345:416009941600994160392294Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF14295e-38156
NC_009674:3073564:308047130804713080764294Bacillus cytotoxicus NVH 391-98 chromosome, complete genomehypothetical protein4e-38156
NC_017208:4294341:429666542966654296958294Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeputative cytoplasmic protein3e-37153
NC_014171:4178746:418107041810704181363294Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-37153
NC_011725:4288309:429063342906334290926294Bacillus cereus B4264 chromosome, complete genomesporulation protein YqfC3e-37153
NC_011772:4255161:425747142574714257764294Bacillus cereus G9842, complete genomesporulation protein YqfC3e-37153
NC_004722:4244730:424705442470544247347294Bacillus cereus ATCC 14579, complete genomehypothetical Cytosolic Protein3e-37153
NC_002570:1426000:144473614447361445029294Bacillus halodurans C-125, complete genomehypothetical protein1e-23108
NC_009633:3055413:306761230676123067887276Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein4e-1167
NC_021182:2192718:221293322129332213214282Clostridium pasteurianum BC1, complete genomesporulation protein YqfC1e-0858.5
NC_020291:1014333:102926610292661029547282Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomesporulation protein YqfC4e-0857
NC_008261:2524913:252814225281422528438297Clostridium perfringens ATCC 13124, complete genomesporulation protein YqfC2e-0651.6
NC_008593:1704207:170749317074931707780288Clostridium novyi NT, complete genomehypothetical protein5e-0649.7