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Query: NC_005945:3615623:3616219 Bacillus anthracis str. Sterne, complete genome

Start: 3616219, End: 3617121, Length: 903

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:3555506:355610235561023557004903Bacillus cereus NC7401, complete genomedipicolinate synthase, A subunit2e-173607
NC_011658:3603009:360360536036053604507903Bacillus cereus AH187 chromosome, complete genomedipicolinate synthase subunit A2e-173607
NC_017200:3655496:365728936572893658191903Bacillus thuringiensis serovar finitimus YBT-020 chromosome,dipicolinate synthase subunit A2e-172605
NC_003909:3587695:358829135882913589193903Bacillus cereus ATCC 10987, complete genomedipicolinate synthase2e-172605
NC_014103:3985897:398650239865023987401900Bacillus megaterium DSM319 chromosome, complete genomedipicolinic acid synthetase subunit A4e-125447
NC_019903:2578966:260133026013302602265936Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,dipicolinic acid synthetase, A subunit4e-54211
NC_015573:2463123:251337125133712514255885Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeD-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein2e-50199
NC_019978:686362:695644695644696522879Halobacteroides halobius DSM 5150, complete genomeprephenate dehydrogenase3e-47189
NC_014721:1028841:102884110288411029719879Caldicellulosiruptor kristjanssonii 177R1B chromosome, completed-isomer specific 2-hydroxyacid dehydrogenase nad-binding protein6e-43174
NC_014652:1758787:177975417797541780641888Caldicellulosiruptor hydrothermalis 108 chromosome, completedipicolinate synthase subunit a1e-41170
NC_016048:1580352:158904915890491589903855Oscillibacter valericigenes Sjm18-20, complete genomedipicolinate synthase A chain6e-30131