Pre_GI: BLASTP Hits

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Query: NC_005945:2175871:2192575 Bacillus anthracis str. Sterne, complete genome

Start: 2192575, End: 2192832, Length: 258

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2175867:219249321924932192750258Bacillus anthracis str. A0248, complete genomehypothetical protein7e-1889.4
NC_003997:2175843:219246921924692192726258Bacillus anthracis str. Ames, complete genomehypothetical protein7e-1889.4
NC_007530:2175967:219259321925932192850258Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-1889.4
NC_014335:2151404:216876021687602169017258Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-1889.4
NC_005957:2196000:221212422121242212381258Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-1889.4
NC_011773:2239753:225642322564232256680258Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-1889.4
NC_014171:2177353:219504321950432195300258Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-1788.2
NC_011725:2206000:222289922228992223156258Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-1788.2
NC_011772:2166000:218246621824662182723258Bacillus cereus G9842, complete genomehypothetical protein2e-1788.2
NC_012472:2240000:225623022562302256487258Bacillus cereus 03BB102, complete genomehypothetical protein1e-1685.1
NC_011658:2275864:229195422919542292211258Bacillus cereus AH187 chromosome, complete genomehypothetical protein3e-1684