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Query: NC_005945:1103729:1125203 Bacillus anthracis str. Sterne, complete genome

Start: 1125203, End: 1125757, Length: 555

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1103737:112521111252111125765555Bacillus anthracis str. A0248, complete genomehypothetical protein6e-105379
NC_011969:1181302:120149612014961202050555Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-101366
NC_011772:1094534:111636011163601116914555Bacillus cereus G9842, complete genomehypothetical protein2e-99361
NC_003909:1244000:126456712645671265121555Bacillus cereus ATCC 10987, complete genomehypothetical protein2e-99360
NC_014171:1118000:113817811381781138732555Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-99360
NC_004722:1108649:113032411303241130878555Bacillus cereus ATCC 14579, complete genomeIG hypothetical 170283e-99360
NC_017208:1147230:116880311688031169357555Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein8e-99358
NC_011725:1150779:117238611723861172940555Bacillus cereus B4264 chromosome, complete genomeIG hypothetical 170281e-98358
NC_010184:1114000:113236111323611132915555Bacillus weihenstephanensis KBAB4, complete genomeIG hypothetical 170281e-97354