Pre_GI: BLASTP Hits

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Query: NC_005945:1103729:1123048 Bacillus anthracis str. Sterne, complete genome

Start: 1123048, End: 1123332, Length: 285

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1103737:112305611230561123340285Bacillus anthracis str. A0248, complete genomehypothetical protein1e-26118
NC_014335:1094000:111439911143991114683285Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-26118
NC_010184:1114000:113019811301981130482285Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein1e-1788.6
NC_003909:1244000:126240512624051262689285Bacillus cereus ATCC 10987, complete genomehypothetical protein7e-1475.9
NC_011725:1150779:117015411701541170438285Bacillus cereus B4264 chromosome, complete genomehypothetical protein1e-1375.1
NC_004722:1108649:112809511280951128376282Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-1271.2
NC_017208:1147230:116664611666461166927282Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein2e-1270.9