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Query: NC_005945:1103729:1119864 Bacillus anthracis str. Sterne, complete genome

Start: 1119864, End: 1120250, Length: 387

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014335:1094000:111121311112131111599387Bacillus cereus biovar anthracis str. CI chromosome, completespore germination protein PE1e-70264
NC_012659:1103737:111987211198721120258387Bacillus anthracis str. A0248, complete genomespore germination protein GerPE4e-70263
NC_011969:1181302:119614611961461196532387Bacillus cereus Q1 chromosome, complete genomespore germination protein pe1e-67254
NC_017208:1147230:116346111634611163847387Bacillus thuringiensis serovar chinensis CT-43 chromosome, completespore germination protein PE4e-67253
NC_003909:1244000:125921612592161259602387Bacillus cereus ATCC 10987, complete genomespore germination protein GerPE5e-67252
NC_011772:1094534:111087111108711111257387Bacillus cereus G9842, complete genomespore germination protein GerPE5e-67252
NC_014171:1118000:113276211327621133148387Bacillus thuringiensis BMB171 chromosome, complete genomespore germination protein PE8e-65245
NC_011725:1150779:116696911669691167355387Bacillus cereus B4264 chromosome, complete genomespore germination protein GerPE6e-64242
NC_004722:1108649:112490811249081125282375Bacillus cereus ATCC 14579, complete genomeSpore germination protein PE7e-62235
NC_010184:1114000:112701511270151127401387Bacillus weihenstephanensis KBAB4, complete genomespore germination protein PE3e-60229