Pre_GI: BLASTP Hits

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Query: NC_005945:1103729:1109846 Bacillus anthracis str. Sterne, complete genome

Start: 1109846, End: 1110427, Length: 582

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1103737:110985411098541110435582Bacillus anthracis str. A0248, complete genomeputative competence transcription factor2e-110397
NC_014335:1094000:109960510996051100186582Bacillus cereus biovar anthracis str. CI chromosome, completecompetence transcription factor2e-110397
NC_003909:1244000:124460112446011245182582Bacillus cereus ATCC 10987, complete genomecompetence transcription factor, putative8e-106382
NC_011969:1181302:118529111852911185872582Bacillus cereus Q1 chromosome, complete genomecompetence transcription factor2e-105380
NC_004722:1108649:111463211146321115213582Bacillus cereus ATCC 14579, complete genomeCompetence transcription factor3e-105380
NC_011725:1150779:115678911567891157370582Bacillus cereus B4264 chromosome, complete genomecompetence transcription factor3e-105380
NC_014171:1118000:112248611224861123067582Bacillus thuringiensis BMB171 chromosome, complete genomecompetence transcription factor3e-105380
NC_017208:1147230:115324311532431153824582Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecompetence transcription factor1e-104378
NC_011772:1094534:110059811005981101179582Bacillus cereus G9842, complete genomeputative competence transcription factor7e-104375
NC_010184:1114000:111599011159901116571582Bacillus weihenstephanensis KBAB4, complete genomeComK family protein2e-101367
NC_006270:1119000:111912311191231119701579Bacillus licheniformis ATCC 14580, complete genomecompetence transcription factor ComK5e-32137
NC_006322:1119471:111997711199771120555579Bacillus licheniformis ATCC 14580, complete genomeComK5e-32137