Pre_GI: BLASTP Hits

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Query: NC_005945:1103729:1107633 Bacillus anthracis str. Sterne, complete genome

Start: 1107633, End: 1108421, Length: 789

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1103737:110764111076411108429789Bacillus anthracis str. A0248, complete genometrifolitoxin immunity domain protein1e-155548
NC_014335:1094000:109710610971061097897792Bacillus cereus biovar anthracis str. CI chromosome, completetrifolitoxin immunity protein6e-150530
NC_011969:1181302:118276311827631183554792Bacillus cereus Q1 chromosome, complete genometrifolitoxin immunity domain protein2e-144511
NC_011772:1094534:109753410975341098325792Bacillus cereus G9842, complete genometrifolitoxin immunity protein9e-142502
NC_004722:1108649:111162211116221112413792Bacillus cereus ATCC 14579, complete genomeTrifolitoxin immunity protein2e-140498
NC_017208:1147230:115023011502301151021792Bacillus thuringiensis serovar chinensis CT-43 chromosome, completetrifolitoxin immunity protein1e-139495
NC_011725:1150779:115378011537801154571792Bacillus cereus B4264 chromosome, complete genometrifolitoxin immunity protein2e-139494
NC_014171:1118000:111947711194771120268792Bacillus thuringiensis BMB171 chromosome, complete genometrifolitoxin immunity protein9e-138489
NC_016109:3591401:365070236507023651469768Kitasatospora setae KM-6054, complete genomehypothetical protein2e-32139
NC_013947:3347174:335377033537703354543774Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeaminoglycoside phosphotransferase1e-30133
NC_013595:8162181:816877081687708169570801Streptosporangium roseum DSM 43021, complete genomehypothetical protein5e-30131
NC_009921:1668306:171575817157581716522765Frankia sp. EAN1pec, complete genomeputative trifolitoxin immunity protein5e-25114
NC_009921:1668306:169172716917271692458732Frankia sp. EAN1pec, complete genomeputative trifolitoxin immunity protein3e-24112
NC_008278:4023918:402504840250484025833786Frankia alni ACN14a, complete genomeputative Trifolitoxin immunity protein7e-1891.3
NC_016582:3763476:377530837753083776039732Streptomyces bingchenggensis BCW-1 chromosome, complete genomeaminoglycoside phosphotransferase1e-1583.6
NC_008278:4023918:404959140495914050292702Frankia alni ACN14a, complete genomeputative kinase1e-1480.5