Pre_GI: BLASTP Hits

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Query: NC_005810:4306716:4313991 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 4313991, End: 4315364, Length: 1374

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:4065625:4073077407307740744501374Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein0887
NC_008149:318860:3287263287263300991374Yersinia pestis Nepal516, complete genomehypothetical protein0887
NC_004088:4202247:4209699420969942110721374Yersinia pestis KIM, complete genomehypothetical protein0887
NC_008150:4373722:4381174438117443825471374Yersinia pestis Antiqua, complete genomehypothetical protein0887
NC_009381:3680638:3688112368811236894851374Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein0887
NC_014029:452248:4630184630184643911374Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0887
NC_017154:394401:4051704051704065431374Yersinia pestis D106004 chromosome, complete genomehypothetical protein0887
NC_017160:396600:4073704073704087431374Yersinia pestis D182038 chromosome, complete genomehypothetical protein0887
NC_017168:687471:6949236949236962961374Yersinia pestis A1122 chromosome, complete genomehypothetical protein0887
NC_010159:1288000:1297550129755012989861437Yersinia pestis Angola, complete genomehypothetical protein0882
NC_003143:398748:4096564096564108911236Yersinia pestis CO92, complete genomehypothetical protein0797