Pre_GI: BLASTP Hits

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Query: NC_005810:3493607:3495873 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 3495873, End: 3496280, Length: 408

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003198:3586000:360461236046123604971360Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein8e-35145
NC_006511:4119332:411998041199804120339360Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein8e-35145
NC_010468:4455201:446994444699444470303360Escherichia coli ATCC 8739, complete genomeprotein of unknown function DUF14227e-34142
NC_010473:4256000:425949142594914259850360Escherichia coli str. K-12 substr. DH10B, complete genomeconserved inner membrane protein7e-34142
NC_000913:4159090:415979441597944160153360Escherichia coli K12, complete genomeconserved inner membrane protein7e-34142
CU928160:4248621:425100242510024251361360Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein; putative inner membrane protein7e-34142
NC_009648:4656187:465843546584354658794360Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomehypothetical protein2e-32137