Pre_GI: BLASTP Hits

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Query: NC_005810:3493607:3495213 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 3495213, End: 3495860, Length: 648

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010468:4455201:447030344703034471007705Escherichia coli ATCC 8739, complete genometranscriptional regulator, TetR family2e-92338
NC_010473:4256000:425884442588444259491648Escherichia coli str. K-12 substr. DH10B, complete genomeDNA-binding transcriptional repressor2e-92338
NC_000913:4159090:415909041590904159794705Escherichia coli K12, complete genomeDNA-binding transcriptional repressor2e-92338
CU928160:4248621:425029842502984251002705Escherichia coli IAI1 chromosome, complete genomeDNA-binding transcriptional repressor3e-92337
NC_003198:3586000:360498736049873605622636Salmonella enterica subsp. enterica serovar Typhi str. CT18,possible TetR-family trancriptional regulatory protein4e-92337
NC_009648:4656187:465778746577874658419633Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeDNA-binding transcriptional repressor FabR9e-92336
NC_006511:4119332:411933241193324119964633Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCpossible TetR-family trancriptional regulatory protein1e-91335
NC_010939:1633000:165902516590251659657633Actinobacillus pleuropneumoniae serovar 7 str. AP76, completeputative HTH-type transcriptional regulator6e-57220
NC_010278:1625695:165631416563141656946633Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,DNA-binding transcriptional repressor FabR6e-57220
NC_013194:2788299:280499728049972805710714Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completetranscriptional regulator, TetR family1e-22106
NC_003919:4618988:465747546574754658122648Xanthomonas axonopodis pv. citri str. 306, complete genometranscriptional regulator tetR family2e-2099.4
NC_013722:3081459:308688030868803087524645Xanthomonas albilineans, complete genomeputative transcriptional regulator, tetr-family transcription regulator protein3e-2098.2
NC_007645:2294553:231984623198462320478633Hahella chejuensis KCTC 2396, complete genomeTranscriptional regulator6e-2097.4
NC_015556:819503:838253838253838888636Pseudomonas fulva 12-X chromosome, complete genomeregulatory protein TetR3e-1891.7
NC_008699:1816392:183836418383641838969606Nocardioides sp. JS614, complete genomeregulatory protein, TetR3e-1581.6