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Query: NC_005810:2739878:2759703 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 2759703, End: 2760131, Length: 429

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017160:2976683:299231129923112992739429Yersinia pestis D182038 chromosome, complete genomehypothetical protein9e-51198
NC_014029:3047506:306733630673363067764429Yersinia pestis Z176003 chromosome, complete genomehypothetical protein9e-51198
NC_009708:1284555:130255513025551302983429Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeintegral membrane protein9e-51198
NC_009381:1783886:178388617838861784314429Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein9e-51198
NC_008150:2681327:270115727011572701585429Yersinia pestis Antiqua, complete genomehypothetical protein9e-51198
NC_010159:3779129:379692437969243797352429Yersinia pestis Angola, complete genomeintegral membrane protein9e-51198
NC_008149:1317109:133693913369391337367429Yersinia pestis Nepal516, complete genomemembrane protein9e-51198
NC_010634:3368000:336897433689743369402429Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein9e-51198
NC_006624:1952554:197321919732191973641423Thermococcus kodakarensis KOD1, complete genomepredicted permease, containing DUF6 domain2e-2097.8
NC_014828:2038692:206338820633882064251864Ethanoligenens harbinense YUAN-3 chromosome, complete genomeprotein of unknown function DUF6 transmembrane2e-1580.9
NC_014963:4872883:488382148838214884240420Terriglobus saanensis SP1PR4 chromosome, complete genomehypothetical protein2e-1478.2
NC_015577:2203835:220735622073562207769414Treponema azotonutricium ZAS-9 chromosome, complete genomedrug/metabolite transporter, DMT family6e-1476.3
NC_017030:7514500:751722575172257517641417Corallococcus coralloides DSM 2259 chromosome, complete genomehypothetical protein1e-1375.1
NC_009767:3335021:334049833404983340929432Roseiflexus castenholzii DSM 13941, complete genomeprotein of unknown function DUF6 transmembrane1e-1375.1
NC_014961:1071424:107426310742631074682420Desulfurococcus mucosus DSM 2162 chromosome, complete genomehypothetical protein1e-1272
NC_007973:3240866:326261632626163263047432Ralstonia metallidurans CH34 chromosome 1, complete sequenceprotein of unknown function DUF6, transmembrane1e-1271.6
NC_021172:169215:178929178929179360432Hyphomicrobium denitrificans 1NES1, complete genomehypothetical protein1e-1168.6