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Query: NC_005810:2739878:2759333 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 2759333, End: 2759575, Length: 243

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009708:1284555:130218513021851302427243Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein2e-40164
NC_010159:3779129:379655437965543796796243Yersinia pestis Angola, complete genomehypothetical protein2e-40164
NC_008149:1317109:133656913365691336811243Yersinia pestis Nepal516, complete genomehypothetical protein2e-40164
NC_010634:3368000:336953033695303369772243Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein2e-40164
NC_008150:2681327:270078727007872701029243Yersinia pestis Antiqua, complete genomehypothetical protein2e-40164
NC_009381:1783886:178444217844421784684243Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein8e-40162
NC_010465:1273000:129056312905631290805243Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein2e-39160
NC_012962:1661683:168093916809391681157219Photorhabdus asymbiotica, complete genomehypothetical protein1e-24112
NC_014306:2476316:248943524894352489656222Erwinia billingiae Eb661, complete genomeconserved uncharacterized protein3e-21100