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Query: NC_005810:1230976:1243393 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1243393, End: 1245600, Length: 2208

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:3188795:3191858319185831940652208Yersinia pestis D106004 chromosome, complete genomehypothetical protein01159
NC_017168:2626996:2630059263005926322662208Yersinia pestis A1122 chromosome, complete genomehypothetical protein01159
NC_004088:1265730:1268793126879312710002208Yersinia pestis KIM, complete genomehypothetical protein01159
NC_003143:3115933:3130158313015831323652208Yersinia pestis CO92, complete genomehypothetical protein01159
NC_014029:3245778:3248841324884132510482208Yersinia pestis Z176003 chromosome, complete genomehypothetical protein01159
NC_008150:2822689:2836430283643028386372208Yersinia pestis Antiqua, complete genomehypothetical protein01159
NC_008149:1195614:1198677119867712008842208Yersinia pestis Nepal516, complete genomemembrane protein01159