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Query: NC_005810:1230976:1240750 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1240750, End: 1241331, Length: 582

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2626996:263432826343282634909582Yersinia pestis A1122 chromosome, complete genomehypothetical protein6e-102369
NC_017154:3188795:319612731961273196708582Yersinia pestis D106004 chromosome, complete genomehypothetical protein6e-102369
NC_014029:3245778:325311032531103253691582Yersinia pestis Z176003 chromosome, complete genomehypothetical protein6e-102369
NC_003143:3115933:312751531275153128096582Yersinia pestis CO92, complete genomehypothetical protein6e-102369
NC_008150:2822689:283378728337872834368582Yersinia pestis Antiqua, complete genomehypothetical protein6e-102369
NC_008149:1195614:120294612029461203527582Yersinia pestis Nepal516, complete genomehypothetical protein6e-102369
NC_008322:373531:388584388584389369786Shewanella sp. MR-7, complete genomehypothetical protein7e-65246
NC_009720:464078:479819479819480607789Xanthobacter autotrophicus Py2, complete genomehypothetical protein5e-1787.4
NC_010554:2646806:269339726933972694230834Proteus mirabilis HI4320, complete genomeplasmid-related protein6e-1270.5
NC_008686:1960034:196747319674731968294822Paracoccus denitrificans PD1222 chromosome 1, complete sequencehypothetical protein1e-0962.8
NC_009665:2352528:237053323705332371321789Shewanella baltica OS185 chromosome, complete genomehypothetical protein3e-0961.6
NC_016026:1224129:124369712436971244464768Micavibrio aeruginosavorus ARL-13 chromosome, complete genomehypothetical protein7e-0960.5
NC_013716:3708415:371933737193373720140804Citrobacter rodentium ICC168, complete genomehypothetical protein6e-0857.4
NC_005125:4557889:457146645714664572248783Gloeobacter violaceus PCC 7421, complete genomehypothetical protein2e-0652.8