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Query: NC_005810:1230976:1235123 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1235123, End: 1235326, Length: 204

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2626996:264033426403342640537204Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-32138
NC_008150:2822689:282815928281592828362204Yersinia pestis Antiqua, complete genomehypothetical protein1e-32138
NC_008149:1195614:120895212089521209155204Yersinia pestis Nepal516, complete genomehypothetical protein1e-32138
NC_013421:4006085:401824040182404019097858Pectobacterium wasabiae WPP163, complete genomehypothetical protein1e-21101
NC_012962:869295:887993887993888757765Photorhabdus asymbiotica, complete genomesimilar to putative membrane protein2e-1684.3
NC_005810:1230976:123575912357591235959201Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-1272
NC_012962:869295:890274890274891209936Photorhabdus asymbiotica, complete genomehypothetical protein1e-1065.5
NC_012962:869295:889432889432889563132Photorhabdus asymbiotica, complete genomehypothetical protein2e-0961.2