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Query: NC_005810:1130251:1151822 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1151822, End: 1152073, Length: 252

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011294:2053991:206270920627092062960252Salmonella enterica subsp. enterica serovar Enteritidis strhypothetical protein1e-31134
NC_011205:2180598:218972621897262189977252Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein1e-31134
NC_011601:2139188:216761121676112167862252Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein9e-31132
NC_016831:947281:980356980356980589234Salmonella enterica subsp. enterica serovar Gallinarum/pullorumhypothetical protein3e-29127
NC_011274:2044000:205395120539512054199249Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91hypothetical protein1e-28124
NC_016818:859181:874765874765875010246Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completehypothetical protein2e-21101
NC_008800:2127918:214287921428792143127249Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,exported protein3e-1993.6
NC_012918:1444333:145888014588801459128249Geobacter sp. M21 chromosome, complete genomehypothetical protein8e-1682.4
NC_005773:694990:717658717658717912255Pseudomonas syringae pv. phaseolicola 1448A, complete genomehypothetical protein1e-1582
NC_014910:465980:499891499891500139249Alicycliphilus denitrificans BC chromosome, complete genomehypothetical protein6e-1579.3
NC_010322:5349000:537926653792665379520255Pseudomonas putida GB-1 chromosome, complete genomehypothetical protein1e-1375.1
NC_020829:3434736:344636834463683446613246Pseudomonas denitrificans ATCC 13867, complete genomehypothetical protein3e-1373.9
NC_014614:2643203:264381226438122644057246Clostridium sticklandii, complete genomehypothetical protein1e-1272
NC_009997:2352948:236467223646722364914243Shewanella baltica OS195, complete genomehypothetical protein3e-1063.9
NC_016048:2873669:290309129030912903333243Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein2e-0961.2