Pre_GI: BLASTP Hits

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Query: NC_005810:1130251:1143218 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1143218, End: 1143508, Length: 291

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009381:2939782:295271529527152953038324Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-50197
NC_008150:650899:656157656157656480324Yersinia pestis Antiqua, complete genomehypothetical protein1e-50197
NC_008149:3251196:326413032641303264453324Yersinia pestis Nepal516, complete genomehypothetical protein1e-50197
NC_017265:1136000:114075111407511141041291Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein3e-50196
NC_003143:1233128:123942112394211239711291Yersinia pestis CO92, complete genomehypothetical protein3e-50196
NC_004088:3382148:339511433951143395404291Yersinia pestis KIM, complete genomehypothetical protein3e-50196
NC_010159:1417993:142357314235731423722150Yersinia pestis Angola, complete genomehypothetical protein9e-2199