Pre_GI: BLASTP Hits

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Query: NC_004851:191709:207606 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 207606, End: 207773, Length: 168

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007608:97092:110172110172110633462Shigella boydii Sb227 plasmid pSB4_227, complete sequencehypothetical protein7e-27119
NC_011749:34056:535635356354099537Escherichia coli UMN026 plasmid p1ESCUM, complete sequencenuclease7e-27119
NC_017319:192482:207489207489207656168Shigella flexneri 2002017 plasmid pSFxv_1, complete sequencehypothetical protein5e-26116
NC_010660:175200:190143190143190643501Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence3e-22103
NC_007607:87000:104290104290104520231Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequencehypothetical protein1e-1788.2
NC_013222:615948:631046631046631489444Robiginitalea biformata HTCC2501, complete genomepredicted micrococcal nuclease-like protein1e-0858.2
NC_013416:1588369:159322915932291593729501Aggregatibacter actinomycetemcomitans D11S-1, complete genomeprotein ParB4e-0753.5
NC_016513:1924242:192915919291591929659501Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeprotein ParB4e-0753.5
NC_014972:210500:217951217951218613663Desulfobulbus propionicus DSM 2032 chromosome, complete genomenuclease4e-0753.5
NC_012918:2758775:279392827939282794467540Geobacter sp. M21 chromosome, complete genomenuclease6e-0752.8
NC_007517:3430237:344916434491643449706543Geobacter metallireducens GS-15, complete genomeSNase-like nuclease2e-0650.8
NC_008751:2988235:300617030061703006868699Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomenuclease (SNase domain protein)4e-0650.1
NC_012796:4693500:472231247223124722971660Desulfovibrio magneticus RS-1, complete genomeputative nuclease8e-0649.3
NC_008786:4070753:407453540745354074996462Verminephrobacter eiseniae EF01-2, complete genomenuclease (SNase domain protein)8e-0648.9