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Query: NC_004851:191709:204097 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 204097, End: 204843, Length: 747

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017319:192482:203974203974204726753Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceF pilin acetylation protein2e-120431
NC_010660:175200:188255188255189001747Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequencetype IV secretion-like conjugative transfer system pilin acetylase TraX2e-120431
NC_007608:97092:108224108224108970747Shigella boydii Sb227 plasmid pSB4_227, complete sequenceF pilin acetylation protein2e-120431
NC_007607:87000:101371101371102117747Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceF pilin acetylation protein4e-120430
NC_007414:56508:903109031091056747Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequenceF pilin acetylase1e-112405
NC_007385:157516:175899175899176646748Shigella sonnei Ss046 plasmid pSS_046, complete sequence1e-72272
NC_016846:24500:459494594946674726Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS2,type-F conjugative transfer system pilin acetylase TraX2e-51202
NC_013716:4306695:433824643382464338584339Citrobacter rodentium ICC168, complete genome4e-48191
NC_009378:106193:111435111435112172738Yersinia pestis Pestoides F plasmid MT, complete sequenceconjugative transfer fimbrial acetylation protein1e-43176
NC_009787:17344:324793247933237759Escherichia coli E24377A plasmid pETEC_35, complete sequencetype-F conjugative transfer system pilin acetylase TraX2e-1996.3
NC_013285:1:152471524715981735Cronobacter turicensis plasmid pCTU3, complete sequencehypothetical protein7e-1787.8
NC_013722:1785692:179032317903231790991669Xanthomonas albilineans, complete genomeputative f pilin acetylation protein2e-0756.6