Pre_GI: BLASTP Hits

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Query: NC_004741:3240909:3249879 Shigella flexneri 2a str. 2457T, complete genome

Start: 3249879, End: 3250223, Length: 345

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3289853:329882332988233299167345Shigella flexneri 2002017 chromosome, complete genomeThreonine dehydratase operon activator protein7e-62235
NC_004337:3249791:325876132587613259105345Shigella flexneri 2a str. 301, complete genomethreonine dehydratase operon activator protein7e-62235
NC_008258:3224721:323369132336913234035345Shigella flexneri 5 str. 8401, complete genomethreonine dehydratase operon activator protein7e-62235
NC_007613:2981829:298936229893622989706345Shigella boydii Sb227, complete genomethreonine dehydratase operon activator protein7e-62235
NC_002695:3994970:400688340068834007227345Escherichia coli O157:H7 str. Sakai, complete genomethreonine dehydratase operon activator protein3e-61233
NC_013941:3884725:389663838966383896982345Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeThreonine dehydratase operon activator protein3e-61233
NC_011748:3608917:362081836208183621174357Escherichia coli 55989, complete genomeDNA-binding transcriptional activator TdcR3e-61233
CP002516:613462:620771620771621127357Escherichia coli KO11, complete genomeDNA-binding transcriptional activator TdcR3e-61233
CU928160:3344746:335370333537033354059357Escherichia coli IAI1 chromosome, complete genomeThreonine dehydratase operon activator protein3e-61233
CU928145:3608917:362081836208183621174357Escherichia coli 55989 chromosome, complete genomeThreonine dehydratase operon activator protein3e-61233
NC_011741:3344746:335370333537033354059357Escherichia coli IAI1 chromosome, complete genomeDNA-binding transcriptional activator TdcR3e-61233
NC_016902:613462:620771620771621127357Escherichia coli KO11FL chromosome, complete genomeDNA-binding transcriptional activator TdcR3e-61233
NC_011415:3523364:353527735352773535621345Escherichia coli SE11 chromosome, complete genomeDNA-binding transcriptional activator TdcR3e-61233
NC_010498:3488513:349748234974823497826345Escherichia coli SMS-3-5, complete genomethreonine dehydratase operon activator protein2e-59226
NC_012947:630757:639907639907640263357Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeDNA-binding transcriptional activator TdcR8e-59225
NC_011750:3768692:378059337805933780949357Escherichia coli IAI39 chromosome, complete genomeDNA-binding transcriptional activator TdcR8e-59225
NC_010468:613812:622962622962623306345Escherichia coli ATCC 8739, complete genomethreonine dehydratase operon activator protein1e-58224
NC_011751:3710786:372268837226883723044357Escherichia coli UMN026 chromosome, complete genomeDNA-binding transcriptional activator TdcR2e-57220
CP002185:3475991:348508434850843485302219Escherichia coli W, complete genomethreonine dehydratase operon activator protein6e-36149
NC_010658:3014371:301953630195363019754219Shigella boydii CDC 3083-94, complete genomethreonine dehydratase operon activator protein6e-36149
AC_000091:3258377:326723532672353267453219Escherichia coli W3110 DNA, complete genomeDNA-binding transcriptional activator8e-33138
NC_009800:3307123:331621833162183316436219Escherichia coli HS, complete genomethreonine dehydratase operon activator protein8e-33138
NC_009801:3595001:360225736022573602475219Escherichia coli E24377A, complete genomethreonine dehydratase operon activator protein8e-33138
NC_010473:3354052:336314733631473363365219Escherichia coli str. K-12 substr. DH10B, complete genomeDNA-binding transcriptional activator8e-33138
NC_012759:3143455:315255031525503152768219Escherichia coli BW2952 chromosome, complete genomeDNA-binding transcriptional activator TdcR8e-33138
NC_012967:3191319:320041432004143200632219Escherichia coli B str. REL606 chromosome, complete genomeDNA-binding transcriptional activator TdcR8e-33138
NC_000913:3256307:326540232654023265620219Escherichia coli K12, complete genomeDNA-binding transcriptional activator8e-33138