Pre_GI: BLASTP Hits

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Query: NC_004741:3240909:3245076 Shigella flexneri 2a str. 2457T, complete genome

Start: 3245076, End: 3246284, Length: 1209

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3289853:3294020329402032952401221Shigella flexneri 2002017 chromosome, complete genomeputative kinase0764
NC_004337:3249791:3253958325395832551661209Shigella flexneri 2a str. 301, complete genomeacetate/propionate kinase0764
NC_008258:3224721:3228888322888832300961209Shigella flexneri 5 str. 8401, complete genomeputative kinase0764
NC_013941:3884725:3891836389183638930561221Escherichia coli O55:H7 str. CB9615 chromosome, complete genomekinase0759
NC_016902:613462:6247096247096259171209Escherichia coli KO11FL chromosome, complete genomeacetate kinase0756
NC_011415:3523364:3530475353047535316831209Escherichia coli SE11 chromosome, complete genomepropionate/acetate kinase0756
CP002516:613462:6247096247096259171209Escherichia coli KO11, complete genomeacetate kinase0756
CP002185:3475991:3480156348015634813641209Escherichia coli W, complete genomepropionate kinase/acetate kinase C, anaerobic0756
NC_002695:3994970:4002081400208140033011221Escherichia coli O157:H7 str. Sakai, complete genomeacetate/propionate kinase0756
CU928145:3608917:3616028361602836172481221Escherichia coli 55989 chromosome, complete genomepropionate kinase/acetate kinase C, anaerobic0756
NC_011748:3608917:3616028361602836172481221Escherichia coli 55989, complete genomepropionate/acetate kinase0756
NC_010468:613812:6269006269006281081209Escherichia coli ATCC 8739, complete genomeacetate kinase0756
NC_011741:3344746:3348913334891333501331221Escherichia coli IAI1 chromosome, complete genomepropionate/acetate kinase0756
NC_011751:3710786:3717898371789837191181221Escherichia coli UMN026 chromosome, complete genomepropionate/acetate kinase0756
CU928160:3344746:3348913334891333501331221Escherichia coli IAI1 chromosome, complete genomepropionate kinase/acetate kinase C, anaerobic0756
NC_007613:2981829:2984560298456029857801221Shigella boydii Sb227, complete genomeputative kinase0756
NC_009800:3307123:3311290331129033124981209Escherichia coli HS, complete genomepropionate kinase0754
NC_012759:3143455:3147622314762231488301209Escherichia coli BW2952 chromosome, complete genomepropionate/acetate kinase0754
NC_012947:630757:6438456438456450531209Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completepropionate/acetate kinase0754
NC_009801:3595001:3597329359732935985371209Escherichia coli E24377A, complete genomepropionate kinase0754
NC_011750:3768692:3775803377580337770231221Escherichia coli IAI39 chromosome, complete genomepropionate/acetate kinase0754
NC_010473:3354052:3358219335821933594391221Escherichia coli str. K-12 substr. DH10B, complete genomepropionate kinase/acetate kinase C, anaerobic0754
NC_000913:3256307:3260474326047432616941221Escherichia coli K12, complete genomepropionate kinase/acetate kinase C, anaerobic0754
NC_012967:3191319:3195486319548631967061221Escherichia coli B str. REL606 chromosome, complete genomepropionate/acetate kinase0754
NC_010498:3488513:3492680349268034938881209Escherichia coli SMS-3-5, complete genomepropionate kinase0753
NC_010658:3014371:3023474302347430246821209Shigella boydii CDC 3083-94, complete genomepropionate kinase0751
AC_000091:3258377:3262220326222032635151296Escherichia coli W3110 DNA, complete genomepropionate kinase/acetate kinase C, anaerobic0740
NC_014618:586240:6068286068286080361209Enterobacter cloacae SCF1 chromosome, complete genomeacetate kinase3e-170598
NC_004431:4270305:4310306431030643115261221Escherichia coli CFT073, complete genomeacetate/propionate kinase3e-100365
NC_016613:1877688:1879620187962018808461227Vibrio sp. EJY3 chromosome 1, complete sequencepropionate/acetate kinase1e-98360
NC_002516:891000:9115959115959127791185Pseudomonas aeruginosa PAO1, complete genomeprobable acetate kinase3e-84312
NC_011770:4924127:4925607492560749267911185Pseudomonas aeruginosa LESB58, complete genomeacetate kinase3e-84312
NC_018664:1699618:1717142171714217183261185Clostridium acidurici 9a chromosome, complete genomeacetate kinase AckA4e-82305
NC_004347:3028000:3045849304584930470481200Shewanella oneidensis MR-1, complete genomeacetate/propionate kinase3e-81302
NC_011740:2072173:2075970207597020771841215Escherichia fergusonii ATCC 35469, complete genomeputative acetate/propionate kinase pduW2e-80300
NC_009446:473960:4885854885854897691185Dichelobacter nodosus VCS1703A, complete genomeacetate kinase9e-81300
NC_015565:1163148:1181437118143711826331197Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeacetate kinase7e-80297
NC_008800:1459015:1485159148515914863611203Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,acetate kinase6e-78291
NC_013192:305478:3288753288753300711197Leptotrichia buccalis DSM 1135, complete genomeacetate kinase8e-78291
NC_011661:961129:9678339678339690501218Dictyoglomus turgidum DSM 6724, complete genomeacetate kinase2e-77290
NC_012658:2641446:2649424264942426506171194Clostridium botulinum Ba4 str. 657 chromosome, complete genomeacetate kinase2e-77290
NC_012779:2586175:2588564258856425897631200Edwardsiella ictaluri 93-146, complete genomeacetate kinase, putative1e-77290
NC_009348:3819271:3839069383906938402681200Aeromonas salmonicida subsp. salmonicida A449, complete genomeacetate kinase1e-77290
NC_011297:787932:7969867969867981851200Dictyoglomus thermophilum H-6-12, complete genomeacetate kinase1e-77290
NC_010520:2635750:2654210265421026554031194Clostridium botulinum A3 str. Loch Maree, complete genomeacetate kinase3e-77289
NC_010516:2567911:2579408257940825806011194Clostridium botulinum B1 str. Okra, complete genomeacetate kinase3e-77289
NC_014654:1113116:1132432113243211336791248Halanaerobium sp. 'sapolanicus' chromosome, complete genomeacetate kinase3e-77289
NC_011653:1616423:1617169161716916183891221Thermosipho africanus TCF52B, complete genomeacetate kinase3e-77289
NC_012563:2761570:2765705276570527668981194Clostridium botulinum A2 str. Kyoto, complete genomeacetate kinase2e-77289
NC_009495:2571732:2591182259118225923751194Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeacetate kinase2e-77289
NC_009698:2420484:2435550243555024367431194Clostridium botulinum A str. Hall chromosome, complete genomeacetate kinase2e-77289
NC_009699:2635745:2639880263988026410731194Clostridium botulinum F str. Langeland chromosome, complete genomeacetate kinase6e-77288
NC_017297:2635892:2640027264002726412201194Clostridium botulinum F str. 230613 chromosome, complete genomeacetate kinase6e-77288
NC_011565:190406:1933991933991945921194Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,acetate kinase4e-77288
NC_008570:4009762:4027082402708240282811200Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomeacetate kinase1e-76287
NC_013457:1703201:1726399172639917275921194Vibrio sp. Ex25 chromosome 2, complete genomeacetate kinase1e-76286
NC_016614:1178000:1191406119140611926051200Vibrio sp. EJY3 chromosome 2, complete sequenceacetate kinase1e-76286
NC_017179:1239991:1243388124338812445841197Clostridium difficile BI1, complete genomeacetate kinase2e-76286
NC_013315:1230214:1233611123361112348071197Clostridium difficile CD196 chromosome, complete genomeacetate kinase2e-76286
NC_013316:1225797:1231227123122712324231197Clostridium difficile R20291, complete genomeacetate kinase2e-76286
NC_015958:1422319:1436321143632114375261206Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeacetate kinase5e-76285
NC_014624:2668157:2683151268315126843411191Eubacterium limosum KIST612 chromosome, complete genomeacetate kinase9e-76284
NC_014538:985339:1005923100592310071371215Thermoanaerobacter sp. X513 chromosome, complete genomeacetate kinase7e-76284
NC_010336:733751:7436127436127447661155Francisella philomiragia subsp. philomiragia ATCC 25017, completepropionate kinase 2 / acetate kinase A1e-75283
NC_015637:819233:8212728212728225071236Vibrio anguillarum 775 chromosome chromosome II, complete sequenceacetate kinase2e-75283
NC_016023:267581:2911872911872924101224Bacillus coagulans 36D1 chromosome, complete genomeacetate kinase6e-75281
NC_012214:1438476:1440827144082714420291203Erwinia pyrifoliae Ep1/96, complete genomeAcetate kinase6e-75281
NC_010694:1324250:1326607132660713278091203Erwinia tasmaniensis, complete genomeAcetate kinase7e-75281
NC_014964:1309845:1324503132450313257081206Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeacetate kinase7e-75281
NC_013971:2478676:2494886249488624960881203Erwinia amylovora ATCC 49946 chromosome, complete genomeacetate kinase8e-75281
NC_013961:2441148:2457358245735824585601203Erwinia amylovora, complete genomeAcetate kinase8e-75281
NC_013766:1202713:1219182121918212203751194Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein1e-73277
NC_012488:1159463:1177230117723011784231194Listeria monocytogenes Clip81459, complete genomeacetate kinase5e-73275
NC_019978:1410041:1425828142582814270181191Halobacteroides halobius DSM 5150, complete genomeacetate kinase6e-73275
NC_019978:2189394:2191656219165621928461191Halobacteroides halobius DSM 5150, complete genomeacetate kinase2e-72273
NC_013515:65822:8030980309815021194Streptobacillus moniliformis DSM 12112, complete genomeacetate kinase3e-72272
NC_014364:2322269:2327559232755923288991341Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeacetate kinase1e-71270
NC_015873:2260048:2260048226004822612441197Megasphaera elsdenii DSM 20460, complete genomeacetate kinase6e-71268
NC_013929:3206688:3226341322634132275701230Streptomyces scabiei 87.22 chromosome, complete genomeacetate kinase1e-70267
NC_006055:44649:5986259862610521191Mesoplasma florum L1, complete genomeacetate kinase1e-68260
NC_015696:105748:1157031157031168031101Francisella sp. TX077308 chromosome, complete genomeacetate kinase3e-68259
NC_009513:618000:6192136192136204091197Lactobacillus reuteri F275, complete genomeacetate kinase2e-68259
NC_015697:1814128:1816251181625118174471197Lactobacillus reuteri SD2112 chromosome, complete genomeacetate kinase2e-67256
NC_014498:1983740:1985058198505819862481191Streptococcus pneumoniae 670-6B chromosome, complete genomeacetate kinase2e-66253
NC_009663:2056166:2071721207172120729111191Sulfurovum sp. NBC37-1, complete genomeacetate kinase2e-65249
NC_014218:1437931:1456579145657914577511173Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomeacetate kinase4e-65248
NC_003366:255480:2874462874462886421197Clostridium perfringens str. 13, complete genomeacetate kinase1e-64247
NC_008710:621822:6535526535526547661215Borrelia turicatae 91E135, complete genomeacetate kinase2e-64246
NC_007775:2702045:2703599270359927048101212Synechococcus sp. JA-3-3Ab, complete genomeacetate kinase6e-64244
NC_008262:227354:2592772592772604731197Clostridium perfringens SM101, complete genomeacetate kinase3e-63242
NC_016604:1285277:1285277128527712864191143Mycobacterium rhodesiae NBB3 chromosome, complete genomeacetate kinase4e-62238
NC_009714:1084000:1096962109696210981611200Campylobacter hominis ATCC BAA-381, complete genomeacetate kinase3e-60233
NC_019950:481881:5002395002395013961158Mycobacterium canettii CIPT 140060008 complete genomePutative acetate kinase AckA (acetokinase)7e-59228
NC_009525:477093:4951614951614963181158Mycobacterium tuberculosis H37Ra, complete genomeacetate/propionate kinase5e-59228
NC_008769:507000:5246665246665258231158Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative acetate kinase ackA5e-59228
NC_012207:477500:4949994949994961561158Mycobacterium bovis BCG str. Tokyo 172, complete genomeacetate kinase5e-59228
NC_000962:475816:4938514938514950081158Mycobacterium tuberculosis H37Rv, complete genomeacetate/propionate kinase5e-59228
NC_002945:476835:4948704948704960271158Mycobacterium bovis AF2122/97, complete genomeacetate kinase5e-59228
NC_015848:483500:5042205042205053771158Mycobacterium canettii CIPT 140010059, complete genomeputative acetate kinase ACKA5e-59228
NC_002755:472872:4953004953004964571158Mycobacterium tuberculosis CDC1551, complete genomeacetate/propionate kinase5e-59228
NC_009565:479500:4970214970214981781158Mycobacterium tuberculosis F11, complete genomeacetate kinase ackA (acetokinase)5e-59228
NC_012943:476500:4941104941104952671158Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeacetate kinase5e-59228
NC_016768:476500:4941104941104952671158Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeacetate kinase ackA5e-59228
NC_016804:477500:4950004950004961571158Mycobacterium bovis BCG str. Mexico chromosome, complete genomeacetate kinase5e-59228
NC_017026:476500:4941654941654953221158Mycobacterium tuberculosis RGTB327 chromosome, complete genomeacetate kinase A/propionate kinase 25e-59228
NC_015732:773143:7770197770197782181200Spirochaeta caldaria DSM 7334 chromosome, complete genomeacetate kinase3e-58226
NC_010612:835648:8560618560618572271167Mycobacterium marinum M, complete genomeacetate kinase AckA8e-58224
NC_014034:3570034:3570034357003435712181185Rhodobacter capsulatus SB1003 chromosome, complete genomeacetate kinase-31e-56221
NC_017215:1091941:1111042111104211123251284Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,acetate kinase6e-56218
NC_011835:1819707:1838258183825818394901233Bifidobacterium animalis subsp. lactis AD011 chromosome, completeacetate kinase8e-56218
NC_017216:1092751:1111303111130311125351233Bifidobacterium animalis subsp. lactis BLC1, complete genomeacetate kinase8e-56218
NC_012815:1092795:1111332111133211125791248Bifidobacterium animalis subsp. lactis DSM 10140, complete genomeacetate kinase7e-56218
NC_012814:1092860:1111397111139711126441248Bifidobacterium animalis subsp. lactis Bl-04, complete genomeacetate kinase7e-56218
NC_017217:1092916:1111453111145311127001248Bifidobacterium animalis subsp. lactis V9 chromosome, completeacetate kinase7e-56218
NC_017214:1727676:1746160174616017474431284Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeacetate kinase6e-56218
NC_013123:116465:1179471179471191551209Candidatus Sulcia muelleri SMDSEM, complete genomeacetate kinase2e-55216
NC_015422:2806832:2838985283898528402501266Alicycliphilus denitrificans K601 chromosome, complete genomeacetate kinase3e-54213
NC_014313:2059933:2075786207578620769941209Hyphomicrobium denitrificans ATCC 51888 chromosome, completeacetate kinase4e-54212
NC_014210:2597000:2622302262230226233781077Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,acetate kinase1e-53210
NC_018524:4848154:4865976486597648670551080Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeacetate kinase2e-53209
NC_012691:2614603:2702064270206427033051242Tolumonas auensis DSM 9187, complete genomeacetate kinase4e-53209
NC_015731:25493:5053150531517721242Nitrosomonas sp. Is79A3 chromosome, complete genomeAcetate kinase2e-52206
NC_009952:592000:6298326298326309801149Dinoroseobacter shibae DFL 12, complete genomeacetate kinase2e-52206
NC_017033:1525132:1542725154272515439151191Frateuria aurantia DSM 6220 chromosome, complete genomeacetate kinase1e-51204
NC_013947:3406000:3413872341387234149991128Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeacetate kinase4e-51202
NC_000963:110500:1327701327701339271158Rickettsia prowazekii str. Madrid E, complete genomeACETATE KINASE (ackA)1e-50200
NC_017048:452000:4749294749294760861158Rickettsia prowazekii str. GvV257 chromosome, complete genomeacetate kinase1e-50200
NC_017049:109000:1309691309691321261158Rickettsia prowazekii str. Chernikova chromosome, complete genomeacetate kinase1e-50200
NC_017050:110500:1327681327681339251158Rickettsia prowazekii str. Katsinyian chromosome, complete genomeacetate kinase1e-50200
NC_017051:109000:1309721309721321291158Rickettsia prowazekii str. Dachau chromosome, complete genomeacetate kinase1e-50200
NC_017056:110500:1327781327781339351158Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomeacetate kinase1e-50200
NC_017057:110000:1329851329851341421158Rickettsia prowazekii str. RpGvF24 chromosome, complete genomeacetate kinase1e-50200
NC_012988:731790:7381337381337393171185Methylobacterium extorquens DM4, complete genomeacetate kinase4e-50199
NC_007484:3071329:3081189308118930824151227Nitrosococcus oceani ATCC 19707, complete genomeAcetate kinase4e-50199
NC_010172:57500:6013660136613441209Methylobacterium extorquens PA1, complete genomeacetate kinase5e-47188
NC_008314:1825223:1840199184019918413891191Ralstonia eutropha H16 chromosome 2, complete sequenceacetate kinase5e-46185
NC_015064:151607:1729491729491741661218Acidobacterium sp. MP5ACTX9 chromosome, complete genomeacetate kinase4e-46185
NC_014364:2717865:2743017274301727442041188Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeacetate kinase3e-44179
NC_008347:174000:2013662013662025531188Maricaulis maris MCS10, complete genomeacetate kinase4e-42172
NC_013166:1409790:1411967141196714130941128Kangiella koreensis DSM 16069, complete genomeacetate and butyrate kinase5e-30132
NC_010087:460591:461875461875462633759Burkholderia multivorans ATCC 17616 chromosome 3, completeacetate and butyrate kinase3e-2099.8
NC_016751:142237:1491591491591502201062Marinitoga piezophila KA3 chromosome, complete genomebutyrate kinase1e-0861.2
NC_010520:3753875:3768095376809537691891095Clostridium botulinum A3 str. Loch Maree, complete genomebutyrate kinase2e-0654.3